Aging is important: Closing the fouling-cleaning loop

Process units subject to fouling often require regular cleaning, giving rise to repeated cycles of fouling and cleaning. The initial stages of fouling are strongly influenced by the effectiveness of the most recent cleaning step and, similarly, the effectiveness and rate of cleaning are determined by the extent and nature of the deposit layer present on the surface. The optimal operating cycle will therefore be determined by fouling–cleaning interactions. Deposit aging is an important factor in this, as an aged deposit is usually more difficult to clean. Aging therefore introduces an element of choice into fouling–cleaning operating cycles, between in situ 'chemica' methods and ex situ 'mechanica' methods, with associated differences in effectiveness, time, and cost. This paper reports a reformulation of the cleaning scheduling problem to consider the choice of cleaning method, as well as the timing of cleaning. A case study based on a shell-and-tube heat exchanger processing crude oil is used to illustrate the concepts and scope of application of this approach. A novel and more general formulation of the problem, linking design, fouling, and cost aspects via dimensionless groups, is then presented and illustrated with a second case study based on a simpler exchanger model.The full text of this article is embargoed until 2014-09-20 in accordance with the publisher's polic

Marriage, religion and human flourishing: how sustainable is the classic Durkheim thesis in contemporary Europe?

This paper draws on the three waves of the European Values Survey across five countries (Great Britain, Italy, the Netherlands, Northern Ireland, Spain and Sweden) to investigate the relationship between indicators of positive psychology (conceptualised as feelings of happiness and satisfaction with life), religiosity (conceptualised as self-assigned religious affiliation and self-reported religious attendance) and marital status. The results demonstrate that religiosity is, in general, positively correlated with both indicators of positive psychology. Further, across all waves and all countries, the pattern emerges that those respondents who are married are likely to report higher levels of happiness and greater satisfaction in life. These data provide contemporary support for the classic Durkheim thesis linking the two institutions of marriage and religion with human flourishing

Standing up to threats: Translating the two-system model of fear to balance control in older adults

© 2021 The Authors. The ‘two-system’ view of fear builds on traditional conceptualisations of emotion; proposing that the mechanism(s) responsible for behavioural and physiological responses to threat may be distinct from that underpinning the (conscious) emotional experience itself. We empirically tested this notion within a novel, applied context of social and economic importance: fear of falling in older adults. Older adults stood on the edge of a raised platform and were stratified based on whether they reported fear in response to this postural threat. Irrespective of whether participants reported fear, we observed behaviours indicative of postural ‘stiffening’ during the threat condition. Self-reports indicated that participants cognitively monitored these changes in balance, and fear of falling was experienced in those who interpreted these behaviours to imply that harm was likely to occur. Fearful participants exhibited additional changes in balance (increased movement complexity and altered utilisation of sensory feedback) – behaviours likely influenced by attempts to consciously control balance. Taken together, these findings provide novel insight into the systems that regulate behavioural and emotional responses to postural threats. The novel conceptual framework developed from these findings helps identify specific mechanisms that might be targeted for clinical intervention.Economic and Social Research Council SWDTP Postdoctoral Fellowship (Grant Number: ES/V010131/1)

Governors and directors: Competing models of corporate governance

Why do we use the term ‘corporate governance’ rather than ‘corporate direction’? Early British joint stock companies were normally managed by a single ‘governor’. The ‘court of governors’ or ‘board of directors’ emerged slowly as the ruling body for companies. By the nineteenth century, however, companies were typically run by directors while not-for-profit entities such as hospitals, schools and charitable bodies had governors. The nineteenth century saw steady refinement of the roles of company directors, often in response to corporate scandals, with a gradual change from the notion of the director as a ‘representative shareholder’ to the directors being seen collectively as ‘representatives of the shareholders’. Governors in not-for-profit entities, however, were regarded as having broader responsibilities. The term ‘governance’ itself suggests that corporate boards should be studied as ‘political’ entities rather than merely through economic lenses such as agency theory

Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis

Rapid antibiotic susceptibility testing of Mycobacterium tuberculosis is of paramount importance as multiple- and extensively- drug resistant strains of M. tuberculosis emerge and spread. We describe here a virus-based assay in which fluoromycobacteriophages are used to deliver a GFP or ZsYellow fluorescent marker gene to M. tuberculosis, which can then be monitored by fluorescent detection approaches including fluorescent microscopy and flow cytometry. Pre-clinical evaluations show that addition of either Rifampicin or Streptomycin at the time of phage addition obliterates fluorescence in susceptible cells but not in isogenic resistant bacteria enabling drug sensitivity determination in less than 24 hours. Detection requires no substrate addition, fewer than 100 cells can be identified, and resistant bacteria can be detected within mixed populations. Fluorescence withstands fixation by paraformaldehyde providing enhanced biosafety for testing MDR-TB and XDR-TB infections. © 2009 Piuri et al